Calibration and accuracy of the geno2pheno co-receptor algorithm for predicting HIV tropism for single and triplicate measurements of V3 genotype
نویسندگان
چکیده
Background The geno2pheno algorithm (g2p) can give dichotomous tropism based on a selectable “false positive rate” (FPR), reflecting the proportion of individuals inappropriately called “non-R5” and falsely excluded from taking CCR5 antagonists. The effect of replicate genotype measures and different FPR values remains controversial. Here we characterize different FPR “cut-points” in predicting tropism for single vs multiple replicates for interpreting V3 genotype based on data from the clinical trials of Maraviroc (MVC) in experienced patients.
منابع مشابه
Genotypic inference of HIV-1 tropism using population-based sequencing of V3.
BACKGROUND Prior to receiving a drug from CCR5-antagonist class in HIV therapy, a patient must undergo an HIV tropism test to confirm that his or her viral population uses the CCR5 coreceptor for cellular entry, and not an alternative coreceptor. One approach to tropism testing is to examine the sequence of the V3 region of the HIV envelope, which interacts with the coreceptor. METHODS Viral ...
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